Columbia Engineers use DNA nanotechnology to create extremely resilient artificial nanoparticle-based supplies that may be processed via typical nanofabrication strategies.
Columbia Engineering researchers, working with Brookhaven Nationwide Laboratory, report at the moment that they’ve constructed designed nanoparticle-based 3D supplies that may face up to a vacuum, excessive temperatures, excessive stress, and excessive radiation. This new fabrication course of leads to sturdy and totally engineered nanoscale frameworks that not solely can accommodate a wide range of purposeful nanoparticle sorts but additionally may be rapidly processed with typical nanofabrication strategies.
“These self-assembled nanoparticles-based supplies are so resilient that they may fly in house,” says Oleg Gang, professor of
Film visualizes a 3D reconstruction (utilizing FIB-SEM) of silicated DNA-nanoparticle lattice. The reconstruction exhibits gold nanoparticles in lattice (silica construction isn’t seen). The lattice rotates concerning the axis to visualise the construction from a number of instructions. Credit score: Oleg Gang/Columbia Engineering
Materials properties are totally different on the nanoscale and researchers have lengthy been exploring learn how to use these tiny supplies — 1,000 to 10,000 occasions smaller than the thickness of a human hair — in every kind of functions, from making sensors for telephones to constructing quicker chips for laptops. Fabrication strategies, nevertheless, have been difficult in realizing 3D nano-architectures. DNA nanotechnology permits the creation of complexly organized supplies from nanoparticles via self-assembly, however given the smooth and environment-dependent nature of DNA, such supplies may be secure beneath solely a slender vary of situations. In distinction, the newly fashioned supplies can now be utilized in a broad vary of functions the place these engineered constructions are required. Whereas typical nanofabrication excels in creating planar constructions, Gang’s new technique permits for fabrication of 3D nanomaterials which can be changing into important to so many digital, optical, and vitality functions.
Gang, who holds a joint appointment as group chief of the Gentle and Bio Nanomaterials Group at Brookhaven Lab’s Middle for Practical Nanomaterials, is on the forefront of DNA nanotechnology, which depends on folding DNA chain into desired two and three-dimensional nanostructures. These nanostructures change into constructing blocks that may be programmed through Watson-Crick interactions to self-assemble into 3D architectures. His group designs and kinds these DNA nanostructures, integrates them with nanoparticles and directs the meeting of focused nanoparticle-based supplies. And, now, with this new method, the workforce can transition these supplies from being smooth and fragile to stable and sturdy.
This new research demonstrates an environment friendly technique for changing 3D DNA-nanoparticle lattices into silica replicas, whereas sustaining the topology of the interparticle connections by DNA struts and the integrity of the nanoparticle group. Silica works nicely as a result of it helps retain the nanostructure of the mother or father DNA lattice, kinds a sturdy solid of the underlying DNA and doesn’t have an effect on nanoparticles preparations.
“The DNA in such lattices takes on the properties of silica,” says Aaron Michelson, a PhD pupil from Gang’s group. “It turns into secure in air and may be dried and permits for 3D nanoscale evaluation of the fabric for the primary time in actual house. Furthermore, silica gives power and chemical stability, it’s low-cost and may be modified as wanted — it’s a really handy materials.”
To study extra concerning the properties of their nanostructures, the workforce uncovered the transformed to silica DNA-nanoparticles lattices to excessive situations: excessive temperatures above 1,0000C and excessive mechanical stresses over 8GPa (about 80,000 occasions greater than environment stress, or 80 occasions greater than on the deepest ocean place, the Mariana trench), and studied these processes in-situ. To gauge the constructions’ viability for functions and additional processing steps, the researchers additionally uncovered them to excessive doses of radiation and centered ion beams.
“Our evaluation of the applicability of those constructions to couple with conventional nanofabrication strategies demonstrates a really sturdy platform for producing resilient nanomaterials through DNA-based approaches for locating their novel properties,” Gang notes. “This can be a large step ahead, as these particular properties imply that we will use our 3D nanomaterial meeting and nonetheless entry the total vary of typical supplies processing steps. This integration of novel and traditional nanofabrication strategies is required to attain advances in mechanics, electronics, plasmonics, photonics, superconductivity, and vitality supplies.”
Collaborations primarily based on Gang’s work have already led to novel superconductivity and conversion of the silica to conductive and semiconductive media for additional processing. These embody an earlier research revealed by Nature Communications and one just lately revealed by Nano Letters. The researchers are additionally planning to switch the construction to make a broad vary of supplies with extremely fascinating mechanical and optical properties.
“Computer systems have been made with silicon for over 40 years,” Gang provides. “It took 4 many years to push the fabrication all the way down to about 10 nm for planar constructions and gadgets. Now we will make and assemble nanoobjects in a check tube in a few hours with out costly instruments. Eight billion connections on a single lattice can now be orchestrated to self-assemble via nanoscale processes that we will engineer. Every connection could possibly be a transistor, a sensor, or an optical emitter — every could be a bit of knowledge saved. Whereas Moore’s regulation is slowing, the programmability of DNA meeting approaches is there to hold us ahead for fixing issues in novel supplies and nanomanufacturing. Whereas this has been extraordinarily difficult for present strategies, it’s enormously vital for rising applied sciences.”
The research is titled “Resilient Three-Dimensional Ordered Architectures Assembled from Nanoparticles by DNA.”
Authors are: Pawel W. Majewski 1,2, Aaron Michelson3, Marco A. L. Cordeiro1, Cheng Tian1, Chunli Ma1, Kim Kisslinger1, Ye Tian1, Wenyan Liu1, Eric A. Stach3, Kevin G. Yager1, Oleg Gang1, 3, 5
1Center for Practical Nanomaterials, Brookhaven Nationwide Laboratory
2Department of Chemistry, College of Warsaw, Poland
3Department of Utilized Physics and Utilized Arithmetic, Columbia College
4Department of Supplies Science and Engineering, College of Pennsylvania
5Department of Chemical Engineering, Columbia College
The research was supported by US Division of Protection, Military Analysis Workplace, W911NF-19-1-0395. This analysis used assets of the Middle for Practical Nanomaterials and the Nationwide Synchrotron Mild Supply II, that are U.S. DOE Workplace of Science Amenities, at Brookhaven Nationwide Laboratory beneath Contract No. DE-SC0012704. The DNA design work was supported by the US Division of Power, Workplace of Fundamental Power Sciences, Grant DE-SC0008772.